Parts of the M25 and Gallows Corner roundabout are set for closures and delays over the weekend due to an "abnormal load" movement.
A convoy carrying equipment is expected to impact routes within the Romford area, particularly affecting junction 28, as well as junctions 21a through to 19, on the M25.
The slow-moving convoy will be transporting three large pieces of equipment from the Port of Tilbury in Essex, to Millbrook Power Station in Bedfordshire.
The first journey is due to start overnight on Saturday, February 24.
Road users need to plan ahead particularly if intending to travel on the M25 or M1 during this period.
The entry slip road from the A12 onto the M25 anti-clockwise at junction 28 will be closed between 8pm and 5am.
There will also be a temporary holding delay of around 30 minutes at the Gallows Corner roundabout on the A12, expected to take place at around 10pm on Saturday.
The M25 between junction 21a and junction 19 will be closed in both directions from 10pm on Saturday until 6am on Sunday, February 25.
The exit slips from the M1 onto the M25 at junction 6a will also be closed in both directions from 10pm to 6am.
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The movement of the large equipment is part of a scheme to upgrade Millbrook Power Station.
Once completed, the power station will have the capacity to provide instant electricity to power 150,000 households.
The first piece of essential equipment to be transported weighs more than 350 tonnes and is more than 50m long.
With the help of a police escort, the gear is to undertake a 79-mile journey, moving slowly along the route for safety reasons.
The convoy is expected to leave the Port of Tilbury at 5.45pm on Saturday and complete a 12-hour journey which includes parts of the M25 and M1.
It is expected to arrive at Millbrook around 6am on Sunday.
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As well as this first movement, there will be two more journeys on future weekends, each involving similar "abnormal loads".
The full details of the other movements are still to be confirmed, with updates expected to be available on the National Highways website.
National Highways have thanked everyone in advance for their patience whilst this equipment is moved across the road network.
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